Agente: Aerosol

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The ADMIT series–Issues in Inhalation Therapy. 7. Ways to improve pharmacological management of COPD: the importance of inhaler choice and inhalation technique.

Broeders ME, Vincken W, Corbetta L

Since inhalation therapy will probably remain the preferred route of treatment for patients with chronic obstructive pulmonary disease (COPD), it is important to provide helpful information that may assist physicians and nurses in selecting the appropriate device(s) for individual patients as well as prescribing the correct medication. In line with...

PMID: 21808941

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Aerosol delivery device selection for spontaneously breathing patients: 2012.

Ari A, Restrepo RD

Using an electronic literature search for published articles indexed in PubMed between January 1990 and August 2011, the update of this clinical practice guideline is the result of reviewing 84 clinical trials, 54 reviews, 25 in vitro studies, and 7 evidence-based guidelines. The recommendations below are made following the Grading...

PMID: 22472501

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Aerosolization Performance of Jet Nebulizers and Biopharmaceutical Aspects.

Adorni G, Seifert G, Buttini F, Colombo G, Stecanella LA, Krämer I, Rossi A

In this work, 13 jet nebulizers, some of which in different configurations, were investigated in order to identify the biopharmaceutical constraints related to the quality attributes of the medicinal products, which affect their safety, efficiency, compliance, and effectiveness. The aerosolization parameters, including the aerosol output, aerosol output rate, mass median...

PMID: 31405254

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Pilot Randomized Controlled Trial Evaluating the Effect of Hypertonic Saline With and Without Hyaluronic Acid in Reducing Inflammation in Cystic Fibrosis.

Brivio A, Conese M, Gambazza S, Biffi A, Tirelli AS, Russo M, Foà M, Colombo C

Hypertonic saline (HS) has been established as a therapy aimed at restoring the surface liquid of airways liquid and enhancing mucociliary clearance in patients with cystic fibrosis (CF). A formula containing 7% HS and 0.1% hyaluronic acid (HA) is also available, basing its use on the protective effects of HA...

PMID: 27149365

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Long-term safety of glycopyrrolate/eFlow CS in moderate-to-very-severe COPD: Results from the Glycopyrrolate for Obstructive Lung Disease via Electronic Nebulizer (GOLDEN) 5 randomized study.

Ferguson GT, Goodin T, Tosiello R, Wheeler A, Kerwin E

The use of long-acting bronchodilators is an essential component of the management of chronic obstructive pulmonary disease (COPD). The GOLDEN 5 Phase III, randomized, active-controlled, open-label study was conducted to evaluate the long-term safety and tolerability of a nebulized glycopyrrolate formulation (SUN-101) delivered via the investigational eFlow Closed System (eFlow...

PMID: 28919143

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Impact of Hypertonic Saline Solutions on Sputum Expectoration and Their Safety Profile in Patients with Bronchiectasis: A Randomized Crossover Trial.

Herrero-Cortina B, Alcaraz V, Vilaró J, Torres A, Polverino E

The role of hyaluronic acid plus hypertonic saline (HA+HS) as a mucoactive treatment in patients with bronchiectasis is still unknown. This study evaluated whether HA+HS solution enhances similar sputum quantity with better safety profile than HS alone in patients with bronchiectasis.In this double-blind randomized crossover trial, three solutions (7% HS;...

PMID: 29878856

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Effect of terbutaline combined with budesonide in treatment of bronchial asthma and rehabilitation nursing.

Ruihong Z, Lu W, Xiaoli L

Terbutaline aerosol and budesonide suspension are commonly used in the treatment of bronchial asthma, and budesonide suspension has local high efficiency and anti-inflammatory effects. In this paper, we selected 240 patients with bronchial asthma and randomly divided them into two groups. The experimental group was treated with atomization inhalation of...

PMID: 30463820

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Aerosol Medications for Treatment of Mucus Clearance Disorders.

Rubin BK

Airway mucus hypersecretion and secretion retention can result from inflammation, irritation, stimulation, or mucus-producing tumors. Secretion clearance can be furthered hampered by ciliary dysfunction and by weakness or restrictive lung disease, leading to an ineffective cough. There are a number of different mucoactive medications that have been used to reduce...

PMID: 26070577

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